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KMID : 0606319940100010009
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Journal of Phamacetical Sciences Sookmyung Women s University
1994 Volume.10 No. 1 p.9 ~ p.16
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Pharmacological effect of gamdutang extract on platinum complex toxicity in rats
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Park Ji-Young
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Abstract
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Abstract:
@EN The effects of Gamdutang Extract(GDE) on the toxicity of platinum complex(PtCl4(2-Ceen), Cisplatin) in rats were examined. Experimental groups were treated with 5mg/kg/day platinum complex by intraperitoneal injection and GDE 250mg/kg,
500mg/kg
and
1000mg/kg by oral administration for 5 days. the exposure of platinum complex showed the toxicity at all experimental assay such as gain of body weight, the ratio of organ weight to body weight and the serum parameter. This toxicity was restored
by
GDE
admini stration.
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KEYWORD
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